Saturday, October 3, 2009

Prevalence of diabetes expected of atrial fibrillation, and the incidence among women

Atrial fibrillation is 44% more often and 38% more likely to develop diabetes, when it was present in an adult population - especially among women, according to data published recently.
The researchers assessed the prevalence and incidence of atrial fibrillation among patients with diabetes and 17,372 for the same amount of sex and age matched controls without diabetes type 2 diabetes included in a register of Kaiser Permanente Northwest. The researchers followed the patients without atrial fibrillation for comparison with the incidence of atrial fibrillation, while controlling known risk factors. The data showed that the prevalence of atrial fibrillation was significantly higher in patients with diabetes than in those without (3.6% vs 2.5%, P <.0001).

During an average follow-up of 7.2 years, patients with diabetes without atrial fibrillation initially developed atrial fibrillation with age and sex adjusted rate of 9.1 per 1000 person years against 6.6 per 1000 person-years among patients without diabetes. Diabetes is associated with an increased risk of 26% for atrial fibrillation in women after adjusting for other risk factors (HR = 1.26, 95% CI, 1,08-1,46). Diabetes is not a statistically significant risk factor in men.

Men have a higher prevalence of atrial fibrillation in all age groups irrespective of diabetes, but the difference in prevalence among people with diabetes vs without diabetes was higher among women. Atrial fibrillation is 30% more frequent among men aged 65 to 74 years with diabetes (7.9% vs 6.1%, P <.037), while the prevalence of atrial fibrillation was 61% higher among women with diabetes in the same age group (6.1% vs 3.8%, p =. 002). "These results have a potential impact on public health, especially women and stressed the need for further investigations of mechanical coupling between diabetes and atrial fibrillation," the researchers write.

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